P-148: Predictive Factors for Pregnancy after Intrauterine Insemination: A Retrospective Study of Factors Affecting Outcome

Background: Controlled ovarian hyper stimulation (COH) in conjunction with intrauterine insemination (IUI) is frequently used to treat various causes of infertility in couples. In this study we evaluate the relation between IUI outcomes and infertility with the intent to detect the most important parameters that pertain to a successful IUI. Materials and Methods: In this cross-sectional study, we included 994 IUI cycles in 803 couples who referred to the Royan Institute between 2010 and 2011. All statistical analyses were performed with the SPSS program, chi-square and t-tests. Logistic regression was performed to build a prediction model of the IUI outcome. Results: Overall pregnancy rate per completed cycle (16.5%), ectopic pregnancies (1.8%), miscarriage rate (5.4%), multiple pregnancy rates (17.5%) and live birth rate per cycle (14.5%). Pregnant women were of a lower mean age than nonpregnant women (p=0.01). There was an association between cause of infertility and clinical outcomes (p<0.001). The mean duration of infertility in pregnant women was significantly lower (p=0.002), however body mass index (BMI), type of infertility, endometrial thickness and sperm parameters were not related to IUI success (p>0.05). Logistic regression identified five significant IUI variables [female age (OR: 0.9 CI: 0.91-1.007 p= 0.09), menstrual history (OR: 0.4; CI: 0.2-0.6; p<0.001), duration of infertility (OR: 0.8; CI: 0.7-0.9;p<0.001), total dose of gonadotropin (OR: 1.00; CI: 1.00-1.001;p= 0.01) and volume (OR: 1.1; CI:1.003- 1.2;p=0.04)] which were the most predictive of IUI success. Conclusion: This study defined prognostic factor prognostic factors for pregnancy in COH+IUI. These variables have been integrated into a statistical model to predict the chance of pregnancy in subsequent COH+IUI cycles.